Arbloc CCB Drug Interactions

Amlodipine: Amlodipine may enhance the antihypertensive effects of other antihypertensive drugs such as beta blockers although the combination is generally well tolerated. Enhanced antihypertensive effects may also be seen if used with drugs such as aldesleukin and antipsychotics that can cause hypotension. Amlodipine may modify insulin and glucose responses and therefore diabetic patients may need to adjust their antidiabetic treatment when receiving amlodipine. Amlodipine is extensively metabolized in the liver by the cytochrome P450 isoenzyme CYP3A4, and interactions may occur with other drugs, such as quinidine, sharing the same metabolic pathway, and with enzyme inducers, such as carbamazepine, phenytoin, and rifampicin, and enzyme inhibitors, such as cimetidine, erythromycin, and HIV-protease inhibitors.
Losartan: The antihypertensive effects of losartan may be potentiated by drugs or other agents that lower blood pressure. An additive hyperkalemic effect is possible with potassium supplements, potassium-sparing diuretics, or other drugs that can cause hyperkalemia; losartan and potassium-sparing diuretics should not generally be given together. NSAIDs should be used with caution in patients taking losartan as the risk of renal impairment may be increased, particularly in those who are inadequately hydrated; use of NSAIDs may also attenuate the hypotensive effect of losartan. Losartan and some other angiotensin II receptor antagonists are metabolized by cytochrome P450 isoenzymes and interactions may occur with drugs that affect these enzymes.